The codes are listed by the combination of the safe, the mission name, and a description of where it is in the level.
4-5-1 Dishonored The safe in the sewers past the spot where Corvo gets his gear back. Combo is found by looking past the empty bottles on the shelf behind the safe.
2-8-7 High Overseer Campbell The safe in Dr. Galvani’s residence (Dr. Galvani’s map)
2-1-7 High Overseer Campbell The locked kennel door in the Overseer’s base (Kennel map)
2-0-3 High Overseer Campbell Barracks safe in the Overseer’s base (Backyard map) Combo is found by saving an overseer’s sister
(Varies)
8-7-9
1-3-8
6-5-6
6-7-9
6-9-6 House of Pleasure The safe in the artist’s residence (Artist’s Residence map) uses a different combination each time you play.
4-7-3 The Royal Physician Practchett’s safe in his house. (Drawbridge Way map). Combo is found by following a note to follow the pictures: Crowded place, shipping yard, whale processing
2-9-4 The Royal Physician The safe behind the painting in the wrecked building where the prisoner pen is outside the Sokolov estate (North End map).
9-3-5 Return to the Tower Lord Regent Hiram Burrows’ safe in his private quarters. (Dunwall Tower map).
4-2-8 Flooded District The underwater safe at the start of Central Rudshore (map with Daud’s base).
5-2-8 Flooded District The Old Port District’s sewer safe; it’s the one with the bone charm (Old District Sewers map).